Hormones, Cognition and Dementia Eef Hogervorst

ISBN: 9780511699900

Published: April 9th 2010

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Hormones, Cognition and Dementia  by  Eef Hogervorst

Hormones, Cognition and Dementia by Eef Hogervorst
April 9th 2010 | ebook | PDF, EPUB, FB2, DjVu, AUDIO, mp3, ZIP | 0 pages | ISBN: 9780511699900 | 10.70 Mb

A decade ago, estrogen-containing hormone therapy was viewed as a promising strategy for the prevention and treatment of dementia and age-related cognitive decline. However, treatment trials in women with Alzheimers disease showed that estrogens didMoreA decade ago, estrogen-containing hormone therapy was viewed as a promising strategy for the prevention and treatment of dementia and age-related cognitive decline.

However, treatment trials in women with Alzheimers disease showed that estrogens did not reverse cognitive impairment, and clinical trials in healthy older women indicated that estrogens did not prevent cognitive decline. The Womens Health Initiative Memory Study trial even suggested an increased risk of dementia with treatment late in life. What happened? How are we to understand these findings? What are the implications for middle-age and older women? What about testosterone, and what about men? And where do we go from here?This book brings together world-renowned experts in basic and clinical research on sex steroids, aging, and cognition to summarize existing findings, present new data, and offer challenging hypotheses on the following hot topics:Why estrogens and estrogen-containing hormone therapy were ineffective for treating women with dementia.Why hormone therapy actually increases dementia risk in some older women.Whether the same may be true for testosterone treatment in older men.Whether there are other related approaches to prevent or treat cognitive aging and dementia.Abundant evidence from basic science studies supports the biological plausibility of estrogens (and perhaps androgens) a effective treatments for cognitive aging and dementia.

Chapters within this book present compelling evidence from epidemiology, genetics, and basic cell culture and animal research that shed light on the above questions and offer innovative solutions with novel treatments and appropriate risk and benefit assessments for clinicians and patients.



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